Table 4 Lyophilized biologic effects on routine blood indices (mean ± SD).

5-fold

Pre-dose

12.23 ± 4.70^a

65.67 ± 15.93^b

6.87 ± 1.52^c

21.30 ± 14.91^d

5.60 ± 0.75^e

0.57 ± 0.05^f

15 d

13.27 ± 1.63^a

73.07 ± 7.82^b

6.23 ± 0.69^c

13.80 ± 8.12^d

6.73 ± 3.67^e

0.17 ± 0.09^f

30 d

13.95 ± 3.24^a

65.40 ± 9.83^b

5.10 ± 0.73^c

25.87 ± 8.15^d

3.07 ± 1.39^e

0.27 ± 0.17^f

10-fold

Pre-dose

13.06 ± 0.84^a

66.73 ± 0.74^b

7.27 ± 0.12^c

20.17 ± 2.76^d

5.57 ± 20.1^e

0.27 ± 0.12^f

15 d

11.70 ± 2.76^a

67.13 ± 4.86^b

7.07 ± 0.60^c

16.00 ± 6.41^d

9.50 ± 6.53^e

0.30 ± 0.14^f

30 d

12.05 ± 1.47^a

56.97 ± 3.67^b

5.57 ± 0.46^c

33.27 ± 3.15^d

3.73 ± 0.47^e

0.47 ± 0.26^f

Control

Pre-dose

11.93 ± 3.48^a

66.63 ± 5.40^b

7.50 ± 1.07^c

20.43 ± 4.31^d

5.23 ± 1.24^e

0.20 ± 0.08^f

15 d

11.82 ± 1.91^a

66.13 ± 5.90^b

7.20 ± 0.50^c

16.87 ± 8.53^d

9.57 ± 3.96^e

0.23 ± 0.12^f

30 d

12.41 ± 3.88^a

55.30 ± 5.08^b

5.93 ± 1.00^c

31.97 ± 10.83^d

6.43 ± 6.00^e

0.37 ± 0.21^f

5-fold

Pre-dose

11.65 ± 1.93^g

30.83 ± 3.20^h

36.00 ± 7.27ⁱ

33.53 ± 1.46^j

12.00 ± 2.01^k

7.47 ± 0.17^l

15 d

11.49 ± 0.35^g

28.77 ± 1.60^h

33.03 ± 2.25ⁱ

34.00 ± 0.99^j

11.23 ± 0.52^k

7.40 ± 0.22^l

30 d

11.97 ± 0.54^g

28.37 ± 1.89^h

34.00 ± 3.62ⁱ

33.47 ± 1.53^j

1.33 ± 0.76^k

7.00 ± 0.24^l

10-fold

Pre-dose

11.11 ± 1.38^g

28.70 ± 0.51^h

31.77 ± 3.39ⁱ

33.73 ± 0.97^j

10.70 ± 0.86^k

7.43 ± 0.17^l

15 d

11.98 ± 0.98^g

28.70 ± 1.19^h

34.20 ± 1.82ⁱ

33.20 ± 0.91^j

11.37 ± 0.52^k

7.43 ± 0.17^l

30 d

11.57 ± 0.83^g

28.1 ± 1.43^h

32.43 ± 2.26ⁱ

33.07 ± 0.12^j

10.73 ± 0.74^k

6.77 ± 0.26^l

Control

Pre-dose

9.90 ± 0.58 ^g

29.27 ± 1.39^h

28.93 ± 2.29ⁱ

35.13 ± 1.87^j

10.13 ± 0.38^k

7.40 ± 0.14^l

15 d

10.48 ± 0.17^g

28.47 ± 0.48^h

29.80 ± 0.83ⁱ

33.87 ± 2.08^j

10.10 ± 0.62^k

6.80 ± 0.45^l

30 d

11.05 ± 0.27^g

28.20 ± 0.14^h

31.10 ± 0.92ⁱ

33.27 ± 1.99^j

10.37 ± 0.73^k

6.77 ± 0.42^l