Table 5 Lyophilized biologic effects on blood biochemistry (mean ± SD).

5-fold

Pre-dose

0.31 ± 0.01^a

9.62 ± 0.53^b

24.15 ± 4.25^c

115.90 ± 24.80^d

54.45 ± 0.45^e

26.25 ± 0.55^f

15 d

0.36 ± 0.09^a

10.09 ± 0.27^b

19.60 ± 3.00^c

98.40 ± 17.00^d

53.05 ± 5.65^e

28.35 ± 1.55^f

30 d

0.44 ± 0.00^a

9.79 ± 0.14^b

19.20 ± 7.10^c

94.60 ± 39.40^d

44.90 ± 13.40^e

27.75 ± 2.35^f

10-fold

Pre-dose

0.43 ± 0.04^a

9.28 ± 0.92^b

17.95 ± 1.45^c

93.40 ± 5.80^d

53.00 ± 2.90^e

25.75 ± 0.85^f

15 d

0.34 ± 0.05^a

9.98 ± 0.15^b

16.25 ± 1.75^c

79.05 ± 25.55^d

48.35 ± 12.75^e

24.60 ± 3.90^f

30 d

0.44 ± 0.03^a

8.8 ± 1.18^b

16.70 ± 5.30^c

78.80 ± 32.00^d

40.45 ± 11.05^e

24.75 ± 1.05^f

Control

Pre-dose

0.31 ± 0.06^a

8.91 ± 0.17^b

20.05 ± 0.65^c

99.95 ± 0.95^d

46.85 ± 12.23^e

28.95 ± 4.15^f

15 d

0.30 ± 0.05^a

10.16 ± 0.18^b

20.30 ± 0.80^c

120.10 ± 18.90^d

53.60 ± 2.00^e

26.60 ± 0.90^f

30 d

0.33 ± 0.00^a

8.63 ± 0.49^b

16.15 ± 0.75^c

94.15 ± 1.15^d

46.90 ± 0.80^e

27.05 ± 2.05^f