Table 2 Some examples of tumor immunotherapy in combination with CPP.
From: Advances and prospects of cell-penetrating peptides in tumor immunotherapy
Cell penetrating peptide | Sequence | Application strategy | Cancer | References |
|---|---|---|---|---|
iRGD | CRGDKGPDC | siFGL1-siPD-L1-iRGD-loaded nanoparticles | LLC cells | |
iRGD | CRGDKGPDC | iRGD-antiCD3 + PD-1 | Human gastric adenocarcinoma cell lines | |
CHL | Chol-HHHHHHH-AKRGARSTA | 1-methyl-DL-tryptophan (1MT) + siPD-L1 + CHL nanoparticles | 4T1 breast tumor cells | |
LMWP | VSRRRRRRGGRRRR | Trichosanthin + PD-1 + LWMP | CT26 murine colon cancer cells | |
iRGD | CRGDKGPDC | iRGD + PD-1 knockout lymphocytes | Human gastric adenocarcinoma cell lines | |
iRGD | CRGDKGPDC | iRGD-antiCD3 | Human gastric cancer cell lines Human colorectal cancer cell line | |
iRGD | CRGDKGPDC | iRGD + CIML NK | HepG2, SK-Hep-1, HUVEC and iRGD receptor-positive HGC27 cells | |
MPGΔNLS | GALFLGFLGAAGSTMGAWSQPK SKRKV | MPGΔNLS-OVA-loaded nanoparticles | EG7-OVA tumor cells | |
CLIP6 | KVRVRVRVDPPTRVRERVK-NH2 | CLIP6-OVA/CpG | B16-OVA melanoma cells | |
Arg8 | CWWRRRRRRRRCRRRRRRRRCRRRRRRRRC | Cys-Trp-Trp-Arg8-CysArg8-Cys-Arg8-Cys/OVA | – | |
GV1001 | EARPALLTSRLRFIPK | eHSP + GV1001 | Advanced pancreatic cancer, non-small cell lung cancer, melanoma, and other cancers | |
LAH4 | KKALLALALHHLAHLALHLALALKKA | LAH4 + OVA/CpG | Human embryonic kidney 293 cells | |
Antp | RQIKIWFQNRRMKWKK | Antp + OVA | B16-OVA melanoma cells | |
Antp | RQIKIWFQNRRMKWKK | AntpMAPMUC1tet/CpG | B16 melanoma cells | |
iRGD | CRGDKGPDC | ST-4-iRGD | B16F10 melanoma cells 4T1 breast tumor cells | |
HIV-1 Tat49-57 | RKKRRQRRRRAHYNEVTF | HIV-1 Tat49-57/HPV16 E749-57 -GM-CSF DNA-loaded nanoparticles | TC-1 tumor cells | |
MPG | GALFLGFLGAAGSTMGAWSQPKKKRKV | MPG/E7DNA nanoparticles | TC-1 tumor cells | |
LALF32-51 | HYRIKPTFRRLKWKYKGKF | LALF32-51-E7 + Al(OH)3 | TC-1 tumor cells | |
iRGD | CRGDKGPDC | iRGD + IL24 | A549 human lung cancer cells | |
PL1 | PPRRGLIKLKTS | FN-EDB TNC-C PL1 | U87-MG cells and PC3 prostate carcinoma cells | |
C − 1 | – | C − 1 | HeLa cells | |
LinTT1 | AKRGARSTA | LinTT1-NW NP | U87-MG GBM cells | |
PL3 | AGRGRLVR | PL3-AgNP | U87MG cells and PC3 prostate carcinoma cells |
