Fig. 6 | Scientific Reports

Fig. 6

From: CNS resident macrophages exhibit region-specific states and immunogenic responses during Rbpj-deficient brain arteriovenous malformation

Fig. 6

Iba1 + cells within cortical high-Iba + density zones showed altered cell morphologies by P14 and P21 in Rbpj-mutant mice, as compared to controls. (A–B) High magnification images of Iba1 + cells from P14 controls and mutants. (A′, B′–B′′′) Cell tracings of Iba1 + cells showed morphological changes in P14 mutant microglia. (E–F) High magnification images of Iba1 + cells from P21 controls and mutants. (E′, F′–F′′) Cell tracings of Iba1 + cells showed morphological changes in P21 mutant microglia. Quantification of cell body areas shown in (C) P14 (P = 0.0410) and (G) P21 (P = 0.0388); quantification of cell process length shown in (D) P14 (P < 0.0001) and (H) P21 (P = 0.0002). Black cells in images represent Iba1 + cells; in illustrations, cell bodies are grey, and processes are black. A sample size of n = 4 for both control and mutant groups was used.

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