Table 4 Subgroups analysis for association of lp(a) with MACE.

From: The nonlinear association between lipoprotein(a) and major adverse cardiovascular events in acute coronary syndrome patients with three-vessel disease

 

T1

T2

T3

 

HR (95% CI)

HR (95% CI)

HR (95% CI)

P for trend

Age

 < 60 years

Ref

0.789 (0.498, 1.250)

1.036 (0.667, 1.610)

0.471

 ≥ 60 years

Ref

1.172 (0.887, 1.548)

1.509 (1.150, 1.981)**

0.006

Sex

 Male

Ref

1.184 (0.904, 1.552)

1.480 (1.129, 1.941)**

0.014

 Female

Ref

0.894 (0.559, 1.433)

1.389 (0.892, 2.164)

0.069

Hypertension

 Yes

Ref

1.133 (0.875, 1.467)

1.366 (1.061, 1.760)*

0.016

 No

Ref

0.837 (0.492, 1.424)

1.536 (0.943, 2.501)

0.025

Diabetes

 Yes

Ref

1.306 (0.926, 1.842)

1.373 (0.972, 1.941)

0.172

 No

Ref

0.903 (0.654, 1.246)

1.372 (1.005, 1.874)*

0.007

Hyperlipidemia

 Yes

Ref

1.181 (0.823, 1.696)

1.209 (0.840, 1.740)

0.552

 No

Ref

0.999 (0.733, 1.361)

1.553 (1.164, 2.073)**

0.001

Stroke

 Yes

Ref

1.061 (0.681, 1.651)

1.336 (0.869, 2.052)

0.310

 No

Ref

1.154 (0.874, 1.523)

1.489 (1.134, 1.956)**

0.011

CKD

    

 Yes

Ref

0.983 (0.623, 1.550)

1.567 (1.030, 2.384)*

0.011

 No

Ref

1.086 (0.825, 1.429)

1.318 (1.000, 1.738)

0.116

  1. Lp(a), lipoprotein(a); MACE, major adverse cardiovascular events; CKD, Chronic kidney disease; HR, hazard ratio; CI, confidence interval. *P < 0.05, **P < 0.01.
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