Table 1 Patient characteristics.

From: FAN score predicts prognosis after platinum-based first-line chemotherapy in patients with metastatic urothelial carcinoma

Characteristic

n = 126

Age, years, range, (median)

43–86

70.0

Sex, N (%)

Male

91

72.2

Female

35

27.8

Primary site, N (%)

Bladder

61

48.4

Upper urinary tract

62

49.2

Both

3

2.4

Surgical removal of primary site, N (%)

Yes

78

61.9

No

48

38.1

Chemotherapy regimen, N (%)

Gemcitabine Cisplatin

77

61.1

Gemcitabine Nedaplatin

49

38.9

Number of chemotherapy cycles, range (median)

Gemcitabine Cisplatin

1–16

4

Gemcitabine Nedaplatin

1–6

3

ECOG PS, N (%)

0

100

79.4

1

24

19.0

 ≥ 2

2

1.6

Metastatic sites, N (%)

Lymph nodes only

34

27.0

Visceral metastasis (lung, liver, or bone)

59

46.8

Local recurrence, other organs

33

26.2

MSKCC risk score, N (%)

0

53

42.1

1

61

48.4

2

12

9.5

Hemoglobin (g/dL), N (%)

 ≥ 10

103

81.7

 < 10

23

18.3

eGFR (ml/min/1.73 m2), range, (median)

7–149

50

eGFR (ml/min/1.73 m2), N (%)

 ≥ 50

67

53.2

 < 50

59

46.8

Fib-4 index, N (%)

 < 3.5

122

96.8

 ≥ 3.5

4

3.2

ALBI score, N (%)

 ≤  − 2.6

51

40.5

 >  − 2.6

75

59.5

NLR, N (%)

 < 5.0

90

71.4

 ≥ 5.0

36

28.6

FAN score, N (%)

0

41

32.5

1

56

44.4

2

28

22.2

3

1

0.8

Treatment after 1st line chemotherapy, N (%)

Immune checkpoint inhibitor

42

33.3

Enfortumab vedotin

5

4.0

Other chemotherapy

32

25.4

Observation period, month, range (median)

0.5–202.9

12.2

  1. ECOG PS Eastern Cooperative Oncology Group performance status, eGFR estimated Glomerular Filtration Rate, Fib-4 Fibrosis-4, ALBI albumin–bilirubin, NLR neutrophil–lymphocyte ratio.