Table 3 Univariable and multivariable Cox regression analysis of OS.

From: FAN score predicts prognosis after platinum-based first-line chemotherapy in patients with metastatic urothelial carcinoma

 

Univariable

Multivariable (Model 1)

Multivariable (Model 2)

HR

95% CI

p value

HR

95% CI

p value

HR

95% CI

p value

Low

High

Low

High

Low

High

Age

continuous (/1 year)

1.01

0.99

1.04

0.321

        

Sex

 Male

Ref

  

–

Ref

  

–

Ref

  

–

 Female

1.48

0.97

2.27

0.071

1.61

1.03

2.51

0.038

1.68

1.08

2.62

0.023

ECOG PS

 0

Ref

  

–

Ref

  

–

Ref

  

–

  ≥ 1

1.00

0.61

1.62

0.991

1.12

0.66

1.90

0.677

1.07

0.64

1.81

0.788

Primary site

 Bladder

Ref

  

–

Ref

  

–

Ref

   

 Upper urinary tract

1.09

0.74

1.60

0.665

1.06

0.71

1.57

0.779

1.04

0.70

1.55

0.839

Hemoglobin

  ≥ 10

Ref

   

Ref

   

Ref

   

  < 10

0.93

0.56

1.54

0.780

0.74

0.43

1.28

0.280

0.83

0.49

1.41

0.495

eGFR

  ≥ 50

Ref

  

–

Ref

  

–

Ref

   

  < 50

1.39

0.95

2.05

0.092

1.36

0.82

2.27

0.235

1.42

0.86

2.35

0.174

Chemotherapy regimen

 GC

Ref

  

–

Ref

  

–

Ref

   

 GN

1.46

0.98

2.16

0.060

1.27

0.75

2.16

0.372

1.14

0.68

1.91

0.619

Chemotherapy regimen& eGFR

 GC GFR ≥ 50

Ref

  

–

        

 GC GFR < 50

1.89

1.09

3.27

0.023

        

 GN GFR ≥ 50

3.31

1.61

6.80

0.001

        

 GN GFR < 50

1.51

0.96

2.38

0.077

        

Visceral metastasis

 No

Ref

  

–

Ref

  

–

Ref

  

–

 Yes

1.05

0.72

1.54

0.786

1.07

0.71

1.62

0.740

1.01

0.67

1.51

0.975

Fib-4 index

  < 3.5

Ref

  

–

Ref

  

–

    

  ≥ 3.5

9.07

2.63

31.35

0.001

11.66

3.13

43.39

 < 0.001

    

ALBI score

  ≤  − 2.6

Ref

  

–

Ref

  

–

    

  >  − 2.6

1.63

1.10

2.41

0.016

1.75

1.15

2.68

0.010

    

NLR

  < 5.0

Ref

  

–

Ref

  

–

    

  ≥ 5.0

1.55

1.02

2.37

0.043

1.58

1.00

2.49

0.049

    

FAN score

  ≤ 1

Ref

  

–

    

Ref

   

  > 2

2.01

1.27

3.18

0.003

    

2.28

1.40

3.70

0.001

  1. ECOG PS Eastern Cooperative Oncology Group performance status, eGFR estimated Glomerular Filtration Rate, GC Gemcitabine Cisplatin, GN Gemcitabine Nedaplatin, Fib-4 Fibrosis-4, ALBI albumin–bilirubin, NLR neutrophil–lymphocyte ratio.
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