Table 3 Growth parameters and medical treatment from discharge to follow-up at 18–24 months corrected age.

From: Risk factors and influence on neurodevelopmental outcomes of neonatal seizures in very low birth weight infants based on nationwide cohort

 

Seizure (-)

(N = 7,174)

Seizure (+)

(N = 425)

P-value

Follow up rate after discharge

7,174/9,344 (76.8%)

425/536 (79.3%)

0.179

 Visit

5,998 (83.6%)

337 (79.3%)

0.020

 No visit

1,176 (16.4%)

88 (20.7%)

  Visit to other hospital

118 (10.0%)

26 (29.5%)

< 0.001

  Telephone survey

992 (84.4%)

27 (30.7%)

  Admitted to hospital

7 (0.6%)

1 (1.1%)

  Post-discharge mortality

59 (5.0%)

34 (38.6%)

GA, weeks

29+ 1 [27+ 3, 31+ 0]

26+ 2 [24+ 5, 28+ 1]

< 0.001

Birthweight, g

1160 [930, 1340]

860 [700, 1100]

< 0.001

Male gender

3,537 (49.3%)

256 (60.2%)

< 0.001

Growth at 18-24months corrected age

 Weight

N = 6,547

N = 359

< 0.001

  <10th

1,204 (18.4%)

147 (40.9%)

  10th -90th

4,937 (75.4%)

203 (56.5%)

  >90th

406 (6.2%)

9 (2.5%)

 Height

N = 6,012

N = 339

< 0.001

  <10th

1,261 (21.0%)

123 (36.3%)

  10th -90th

4,297 (71.5%)

195 (57.5%)

  >90th

454 (7.6%)

21 (6.2%)

 Head circumference

N = 5,098

N = 284

< 0.001

  <10th

1,038 (20.4%)

144 (50.7%)

  10th -90th

3,588 (70.4%)

137 (48.2%)

  >90th

472 (9.3%)

3 (1.1%)

Medical treatment after NICU discharge

 Oxygen treatment

737/6,925 (10.6%)

115/366 (31.4%)

< 0.001

 Ventilator care

207/6,922 (3.0%)

23/365 (6.3%)

< 0.001

 Tracheostomy

36/6,930 (0.5%)

9/366 (2.5%)

< 0.001

 Nasogastric tube feeding

317/6,930 (4.6%)

76/366 (20.8%)

< 0.001

 Ventriculo-peritoneal shunt

48/6,930 (0.7%)

63/365 (17.3%)

< 0.001

 Anti-epileptic medication

77/6,929 (1.1%)

118/365 (32.3%)

< 0.001

 Rehabilitation treatment

2,226/6,889 (32.3%)

284/364 (78.0%)

< 0.001

 Language treatment

418/6,850 (6.1%)

58/349 (16.6%)

< 0.001

 Pulmonary HT medication

46/2,749 (1.7%)

17/137 (12.4%)

< 0.001

Readmission

3,265/6,867 (47.5%)

246/360 (68.3%)

< 0.001

Brain CT/MRI after NICU discharge

 Performed

728/6,878 (10.6%)

145/365 (39.7%)

< 0.001

 Abnormal

405/728 (55.6%)

125/145 (86.2%)

< 0.001

  1. Chi-square test, fisher’s exact test, Mann-Whitney U test.
  2. N; number, GA; gestational age, HT; hypertension, NICU; neonatal intensive care unit, CT; computed tomography, MRI; magnetic resonance imaging.