Fig. 6 | Scientific Reports

Fig. 6

From: Steroid hormone receptors, exome sequencing and treatment responsiveness of breast cancer patient-derived xenografts originated in a South American country

Fig. 6

Whole exome sequencing analysis (WES). Single nucleotide variations (SNV) and variant classification were analyzed in the 8 PDX with different filters: (A) Top 50 genes with SNV alterations. Colors indicate the type of alteration registered. (B) WNT, RAS, Hippo, NOTCH, PI3K and TP53 disrupted pathways are highlighted in pink, and above each pathway line, the altered genes involved are shown. (C) Alterations in breast cancer driver genes. Tumor mutation burden (TMB) of each PDX is shown at the top of Figures A and B, and estrogen receptors (ER), progesterone receptors (PR), HER2 and KI67 expression at the bottom of Figures A and C.

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