Fig. 6 | Scientific Reports

Fig. 6

From: Development of immune-derived molecular markers for preeclampsia based on multiple machine learning algorithms

Fig. 6

Gene–Drug Interaction Network and Molecular Docking. (A) Interaction network of hub PE.ISGs and small-molecule compounds. Red represents the hub PE.ISGs, light blue represents small-molecule compounds in the cMAP database, and dark blue represents small-molecule compound contained in DGIdb database. (B-D) Visualization of the docking results. RXRG with alitretinoin (B), RXRG with tretinoin (C), and RXRG with acitretin (D). From left to right, the panels show the global docking map and the interaction forces map, respectively.PE.ISG, preeclampsia immune source–related gene. The color gradient on the protein surface changes from green to orange to red, indicating a transition from hydrophilic to hydrophobic amino acids. The blue dashed lines represent hydrogen bonds, light blue dashed lines represent weak hydrogen bonds, gray dashed lines represent hydrophobic forces, yellow dashed lines represent ionic bonds, and green dashed lines represent π-π conjugation.

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