Table 2 Organ uptake of [89Zr]Zr-AAV9-CMV-fLuc at different time points (up to 48 h) post-injection in BALB/c mice as determined from PET-analysis (SUV-values).

From: PET imaging of AAV9 and AAVBR1 trafficking in normal mice

Organs/

tissues

5 min

10 min

15 min

2 h

4 h

24 h

48 h

(n = 6)

(n = 6)

(n = 6)

(n = 5)

(n = 6)

(n = 8)

(n = 8)

Lungs

4.58 ± 0.81

3.93 ± 0.77

3.78 ± 0.78

1.59 ± 0.61

1.45 ± 0.33

0.72 ± 0.57

1.33 ± 0.15

Kidney

3.36 ± 0.77

3.21 ± 0.67

3.19 ± 0.66

2.82 ± 0.49

2.46 ± 0.46

2.28 ± 0.39

2.01 ± 0.37

Liver

10.17 ± 1.21

11.54 ± 1.17

12.04 ± 1.27

12.23 ± 1.30

11.98 ± 1.61

11.47 ± 1.12

11.73 ± 1.59

Bone

(Femur)

1.42 ± 0.23

1.55 ± 0.17

1.58 ± 0.26

1.80 ± 0.35

1.91 ± 0.42

7.29 ± 2.45

3.04 ± 0.66

Muscle

0.52 ± 0.04

0.55 ± 0.04

0.51 ± 0.06

0.34 ± 0.11

0.33 ± 0.06

0.37 ± 0.11

0.34 ± 0.07

Brain

0.78 ± 0.22

0.61 ± 0.13

0.58 ± 0.18

0.30 ± 0.08

0.39 ± 0.26

0.19 ± 0.04

0.19 ± 0.03

Spleen

4.06 ± 0.90

4.10 ± 0.87

4.15 ± 0.67

3.79 ± 0.83

3.65 ± 0.54

7.29 ± 2.45

4.74 ± 1.19

Gut

1.68 ± 1.10

1.34 ± 0.73

1.36 ± 0.72

3.14 ± 0.68

3.33 ± 1.13

1.02 ± 0.42

0.73 ± 0.17

Vertebra

2.01 ± 0.73

1.76 ± 0.49

1.60 ± 0.42

1.38 ± 0.23

1.41 ± 0.11

1.03 ± 0.30

2.46 ± 0.49

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