Fig. 1

Gene Set Enrichment Analysis plot illustrating the enrichment of the gene set “Regulation of Natural Killer Cell Mediated Immunity” in the context of COVID-19 outcomes. The green curve represents the running enrichment score (ES), which reflects the degree to which the gene set is overrepresented at the top of the ranked gene list. A positive ES (ES > 0.4) indicates significant enrichment of these genes at the top of the list, suggesting their upregulation. The vertical black lines correspond to the positions of individual genes from the gene set in the ranked list. The concentration of these lines near the top indicates a strong gene set enrichment, suggesting an important role for natural killer cell regulation in the immune response of the studied patients.