Fig. 4

Protein–chemical interaction using the STRITH software in late recurrence. In the network, proteins were represented as nodes, and the thickness of the connecting lines indicated the degree of association between the proteins or chemicals. A peptide that was centrally located and interacts with multiple other peptides was referred to as a ‘hub’ peptide. Gray line was peptide-peptide interaction, green line was peptide-drug interaction, red line was drug-drug interaction. Circle represented network interaction of peptides that were found in late recurrence.