Table 1 Univariate and multivariate analysis of the survival of CCA patients.
Variable | N = 81 (%) | MST (month) (95%CI) | Univariate | Multivariate | ||
|---|---|---|---|---|---|---|
HR (95%) | p-value | HR (95%) | p-value | |||
Age (Median) | ||||||
<63 | 45 (55%) | 19.70 (13.64–25.76) | 1 | - | ||
≥63 | 36 (45%) | 19.70 (14.11–25.29) | 1.27 (0.77–2.09) | 0.355 | - | - |
Gender | ||||||
Male | 50 (62%) | 26.80 (13.83–39.77) | 1 | - | ||
Female | 31 (38%) | 18.20 (15.23–21.17) | 1.65 (0.963–2.81) | 0.065 | - | - |
Tumor location | ||||||
iCCA | 49 (60%) | 19.70 (16.37–23.03) | 1 | - | ||
pCCA | 28 (35%) | 21.60 (10.13–33.07) | 0.66 (0.38–1.16) | 0.149 | - | - |
dCCA | 4 (5%) | 5.20 (0-44.60) | 1.203 (0.426–3.39) | 0.727 | - | - |
Surgical margin (R) | ||||||
R0 | 46 (57%) | 22.90(11.24–34.56) | 1 | 1 | ||
R1 | 35 (43%) | 15.90 (12.47–19.33) | 1.70 (1.02–2.82) | 0.039* | 1.42 (0.85–2.38) | 0.185 |
Histological differentiation | ||||||
Well | 65 (80%) | 22.10 (7.200–27.00) | 1 | 1 | ||
Moderately/Poorly | 16 (20%) | 16.60 (8.76–24.44) | 1.89 (1.045-3.40) | 0.031* | 1.83 (1.01–3.34) | 0.047 |
Lymph node status (N) | ||||||
N0 | 47 (58%) | 22.9 (14.57–31.23) | 1 | - | ||
N1 | 34 (42%) | 15.9 (13.59–18.22) | 1.55 (0.93–2.57) | 0.089 | - | - |
TNM stage | ||||||
Early (0-II) | 21 (26%) | 35.8 (2.70–74.30) | 1 | 1 | ||
Late (III-IV) | 60 (74%) | 16.6 (13.17–20.03) | 2.21 (1.19–4.11) | 0.01* | 1.61 (0.85–3.04) | 0.142 |
Recurrent status | ||||||
Early | 34 (42%) | 9 (6.68–11.15) | 7.06 (3.96–12.58) | < 0.001* | 6.36 (3.51–11.35) | < 0.001* |
Late | 47 (58%) | 32.8 (19.77–45.80) | 1 | 1 | ||
