Fig. 1 | Scientific Reports

Fig. 1

From: Intratympanic administration of dexamethasone attenuates radiation induced damage to middle ear mucosa

Fig. 1

Schematic overview of the in vivo studies on SD rats. Sprague–Dawley (SD) rats were randomly divided into control and dexamethasone (DEX) treatment groups before exposure to radiotherapy (RTx). DEX or saline (0.06 mL) was administered via intratympanic (IT) injection for 5 days at a dose of 5 mg/mL (sample volume. = 60 µL). After 30 min, the SD rats received a total cranial radiation dose of 33 Gy in five fractions (5 × 6.6 Gy) over five days. The animals were sacrificed at two different time points (1 month and 4 months) after the completion of RTx to assess both the short- and long-term effects of the combined treatment regimen on the experimental outcomes.

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