Fig. 2

MR estimates of four lipid-lowering target genes on PC. (A) MR estimates of four lipid-lowering target genes on PC in the discovery dataset; (B) MR estimates of four lipid-lowering target genes on PC in the replication dataset. IVW (with 95% CI) from all the primary MR analyses are shown for the effects of LPL, APOC3, ANGPTL3, CETP. Red-filled symbols: IVW pā<ā0.0125. IVW, inverse variance-weighted method; LPL, lipoprotein lipase; ANGPTL3, angiopoietin-like 3; APOC3, Apolipoprotein C-III; CETP, Cholesteryl ester transfer protein.