Table 2 Mendelian randomisation results of lipid traits with risk of pancreatic cancer.

From: Genetic association of lipid-lowering drug target genes with pancreatic cancer: a Mendelian randomization study

Dataset

Exposure

Method

nSNP

Beta

SE

Pval

OR

Low 95%CI

Upper 95%CI

The Discovery Dataset

HDL

Inverse variance weighted

86

āˆ’ā€‰0.196901824

0.100720449

0.050590868

0.821271259

0.674142407

1.000510386

Maximum likelihood

86

āˆ’ā€‰0.197187963

0.099997399

0.048617492

0.821036294

0.67490532

0.99880765

MR Egger

86

0.217982946

0.187209404

0.247566284

1.24356586

0.861614361

1.794835505

Weighted median

86

āˆ’ā€‰0.071599887

0.156728197

0.647785238

0.930903288

0.684691332

1.265651968

Weighted mode

86

0.003701173

0.167700568

0.982443745

1.00370803

0.722533176

1.394302495

LDL

Inverse variance weighted

79

0.037162288

0.088410666

0.674239167

1.03786144

0.872735613

1.234229877

Maximum likelihood

79

0.037879562

0.08228174

0.645254877

1.038606137

0.883916526

1.220367169

MR Egger

79

0.069181206

0.129846996

0.595713139

1.071630378

0.830839281

1.382206754

Weighted median

79

0.048729721

0.12150798

0.688389698

1.049936537

0.827434012

1.332271475

Weighted mode

79

0.073982202

0.111971691

0.510737117

1.07678764

0.864605182

1.341041722

TG

Inverse variance weighted

55

āˆ’ā€‰0.178074619

0.113920939

0.118019167

0.836879974

0.669409259

1.046247989

Maximum likelihood

55

āˆ’ā€‰0.179461969

0.106198886

0.091053444

0.835719734

0.678675765

1.029103307

MR Egger

55

āˆ’ā€‰0.371899823

0.175701151

0.039001078

0.689423303

0.488569239

0.97284981

Weighted median

55

āˆ’ā€‰0.344522116

0.155391361

0.026614531

0.708558881

0.522521481

0.960832629

Weighted mode

55

āˆ’ā€‰0.378990339

0.143652543

0.010865434

0.684552226

0.516567494

0.907164611

TC

Inverse variance weighted

86

āˆ’ā€‰0.093226281

0.094819949

0.325512611

0.910987338

0.756484389

1.097045678

Maximum likelihood

86

āˆ’ā€‰0.093189218

0.087740356

0.288189329

0.911021102

0.767082964

1.081968297

MR Egger

86

āˆ’ā€‰0.008456514

0.156222973

0.95695929

0.991579142

0.73004176

1.346812263

Weighted median

86

āˆ’ā€‰0.075318113

0.142366529

0.596775143

0.927448406

0.701624787

1.225955185

Weighted mode

86

āˆ’ā€‰0.056451498

0.133669204

0.673856074

0.945112323

0.727280432

1.228188281

The Replication Dataset

LDL

Inverse variance weighted

46

0.07864996

0.207655257

0.70487162

1.081825573

0.720107809

1.625237994

Maximum likelihood

46

0.07968961

0.166419094

0.632046084

1.082950878

0.781537759

1.500609011

MR Egger

46

0.262846982

0.358872507

0.467793383

1.300627684

0.64368672

2.628036778

Weighted median

46

āˆ’ā€‰0.200857543

0.256921602

0.434340735

0.818028957

0.494393321

1.353520257

Weighted mode

46

āˆ’ā€‰0.153466948

0.242190612

0.529509316

0.857729113

0.53357238

1.378818056

HDL

Inverse variance weighted

72

0.110985894

0.161148915

0.491001778

1.117379145

0.814756503

1.532404036

Maximum likelihood

72

0.112106567

0.141021518

0.426636355

1.118632063

0.848491164

1.474779876

MR Egger

72

0.712421422

0.281770426

0.01371707

2.038922378

1.173688539

3.54199971

Weighted median

72

0.435126517

0.236487785

0.065775071

1.545158536

0.972009654

2.456266653

Weighted mode

72

0.512327595

0.2267054

0.026898028

1.669171833

1.070349264

2.603014456

TG

Inverse variance weighted

43

0.050383294

0.157653721

0.749285207

1.05167412

0.772117917

1.432447596

Maximum likelihood

43

0.050670548

0.157987751

0.748419155

1.05197626

0.771834257

1.433797531

MR Egger

43

āˆ’ā€‰0.162956647

0.247284095

0.51358929

0.849628021

0.523282674

1.37949871

Weighted median

43

āˆ’ā€‰0.076364909

0.227791683

0.737443966

0.926478064

0.592836515

1.447889227

Weighted mode

43

āˆ’ā€‰0.085084098

0.21870556

0.699215776

0.918435043

0.598249734

1.409984625

TC

Inverse variance weighted

57

0.09335813

0.182835412

0.609622102

1.09785484

0.767206505

1.571004993

Maximum likelihood

57

0.094851443

0.15426381

0.538643772

1.099495505

0.81260867

1.487666093

MR Egger

57

0.484283745

0.347025255

0.168465454

1.623012102

0.82210615

3.20417051

Weighted median

57

0.188328

0.240542244

0.433667582

1.207229422

0.753418222

1.934387616

Weighted mode

57

0.112222223

0.266283251

0.675047648

1.118761448

0.663854056

1.88539509

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