Table 4 Sensitivity analysis on the association of cholecystectomy with risk of depression among participants with fewer or more comorbidities.

From: Association of cholecystectomy with short-term and long-term risks of depression and suicide

 

No Cholecystectomy

Cholecystectomy

Charlson comorbidity index<2

45,839

3,558

Events, n

2,590

251

Per 1,000 person-y

390.784

30.310

aHR (95% CI)

1.00 (Ref.)

1.10 (0.96-1.26)

Short-term risk (≤3 years)

43,977

3,398

Events, n

728

91

Per 1,000 person-y

377.265

29.146

aHR (95% CI)

1.00 (Ref.)

1.18 (0.92-1.52)

Long-term risk (>3 years)

45,111

3,467

Events, n

1,862

160

Per 1,000 person-y

389.640

30.291

aHR (95% CI)

1.00 (Ref.)

1.07 (0.91-1.26)

Charlson comorbidity index2

21,041

3,130

Events, n

2,070

436

Per 1,000 person-y

156.438

21.988

aHR (95% CI)

1.00 (Ref.)

1.23 (1.10-1.39)***

Short-term risk (≤3 years)

19,714

2,933

Events, n

743

239

Per 1,000 person-y

147.502

20.697

aHR (95% CI)

1.00 (Ref.)

1.48 (1.24-1.77)***

Long-term risk (>3 years)

20,298

2,891

Events, n

1,327

197

Per 1,000 person-y

155.348

22.127

aHR (95% CI)

1.00 (Ref.)

1.09 (0.94-1.27)

  1. Acronyms: aHR, adjusted hazard ratio; CI, confidence interval.
  2. The aHR adjusted for age, sex, household income, smoking status, alcohol consumption, physical activity, body mass index, systolic blood pressure, diastolic blood pressure, fasting serum glucose, total cholesterol, and Charlson comorbidity index.
  3. ***p<0.001.