Fig. 6
From: Identification of new ClpC1-NTD binders for Mycobacterium tuberculosis drug development
Correlation between molecule size and activity. Correlation between different biochemical and biophysical parameters. Shown are: (A) Solvent-accessible surface area (SASA) vs Kd and (B) SASA vs ATPase activity. While the affinity is not correlated with the size of the molecule, the size of a molecule (expressed as SASA) seems to strongly influence if a compound is biochemically active. A dashed reference line is drawn at a SASA of 700 Å2 indicating a possible cutoff for active vs inactive molecules. A grey background shows molecules with a lower Kd (less than 10 μM) in panel (A), as well as molecules with a strong inhibitory effect on ATPase activity (less than 25%) in panel (B).
