Fig. 12 | Scientific Reports

Fig. 12

From: Improvement of carboplatin chemosensitivity in lung cancer cells by siRNA-mediated downregulation of DLGAP1-AS2 expression

Fig. 12

(A) TCGA data shows significant overexpression of GCLC in LUAD tissues compared to normal lung tissues, indicating its potential role in tumor progression. (B) qRT-PCR analysis results following DLGAP1-AS2 siRNA transfection in lung cancer cell lines, illustrating a downregulation of GCLC expression. These findings suggest that DLGAP1-AS2 and carboplatin drug regulate GCLC levels, potentially impacting ferroptosis and glutathione metabolism pathways in lung cancer cells.

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