Table 1 The significant genes for BPH risk in cross-tissue UTMOST analysis.
Gene symbol | CHR | Ensemble ID | Start_hg38 | End_hg38 | Test_score | Pvalue | PFDR |
|---|---|---|---|---|---|---|---|
BCL11A | 2 | ENSG00000119866 | 60,450,520 | 60,554,467 | 21.11211876 | 1.30E−09 | 4.87E−06 |
LINC02433 | 4 | ENSG00000234111 | 157,572,490 | 157,576,154 | 15.54768184 | 1.82E−07 | 0.000341817 |
FGFR3 | 4 | ENSG00000068078 | 1,793,293 | 1,808,872 | 14.39403043 | 3.15E−07 | 0.000393819 |
ANXA5 | 4 | ENSG00000164111 | 121,667,946 | 121,696,995 | 13.11321544 | 7.62E−07 | 0.000673348 |
PEX13 | 2 | ENSG00000162928 | 61,017,225 | 61,051,990 | 12.7865519 | 1.67E−06 | 0.001044328 |
NT5C1B | 2 | ENSG00000185013 | 18,562,871 | 18,589,572 | 12.06350912 | 3.32E−06 | 0.001772672 |
SMIM43 | 4 | ENSG00000164112 | 121,758,881 | 121,765,427 | 13.28313785 | 3.78E−06 | 0.001772672 |
CABS1 | 4 | ENSG00000145309 | 70,334,981 | 70,337,116 | 11.36242854 | 1.03E−05 | 0.004286183 |
AC011242.1 | 2 | ENSG00000229695 | 43,680,465 | 43,681,622 | 11.36791449 | 1.17E−05 | 0.004398295 |
GUCY1A1 | 4 | ENSG00000164116 | 155,666,726 | 155,737,059 | 9.811377233 | 3.22E−05 | 0.010972549 |
EMX1 | 2 | ENSG00000135638 | 72,916,260 | 72,936,071 | 10.43433839 | 3.68E−05 | 0.011485385 |
PTPN13 | 4 | ENSG00000163629 | 86,594,315 | 86,815,171 | 9.219262038 | 4.26E−05 | 0.012296132 |
LOC105372988 | 22 | ENSG00000225676 | 30,182,818 | 30,207,195 | −3.963022499 | 7.40E−05 | 0.019112696 |
OXER1 | 2 | ENSG00000162881 | 42,762,499 | 42,764,135 | 8.992709122 | 7.65E−05 | 0.019112696 |
CABP7 | 22 | ENSG00000100314 | 29,720,003 | 29,731,833 | 9.440220134 | 9.63E−05 | 0.022562167 |
FEZ2 | 2 | ENSG00000171055 | 36,531,805 | 36,646,087 | 8.850195372 | 0.000113971 | 0.0251406 |
MEPE | 4 | ENSG00000152595 | 87,821,398 | 87,846,814 | 8.801099257 | 0.000136295 | 0.028394765 |
CHKB-DT | 22 | ENSG00000205559 | 50,583,026 | 50,595,634 | 7.031066585 | 0.000167794 | 0.033117178 |
INO80B | 2 | ENSG00000115274 | 74,455,087 | 74,457,944 | 7.78906678 | 0.000214979 | 0.039413298 |
MTMR3 | 22 | ENSG00000100330 | 29,883,169 | 30,030,868 | 6.943732695 | 0.000252245 | 0.039413298 |
PAPOLG | 2 | ENSG00000115421 | 60,756,253 | 60,802,086 | 7.893308931 | 0.000246989 | 0.039413298 |
RAPGEF4 | 2 | ENSG00000091428 | 172,735,274 | 173,052,893 | 7.643899152 | 0.000232049 | 0.039413298 |
SPARCL1 | 4 | ENSG00000152583 | 87,473,335 | 87,531,061 | 8.792918369 | 0.00024079 | 0.039413298 |
GLRB | 4 | ENSG00000109738 | 157,076,125 | 157,172,090 | 8.394388133 | 0.000280556 | 0.040464762 |
RPS16P2 | 2 | ENSG00000213729 | 20,155,618 | 20,156,057 | 7.730597346 | 0.000275479 | 0.040464762 |
NCAPH2 | 22 | ENSG00000025770 | 50,508,224 | 50,524,780 | 8.668818045 | 0.00034196 | 0.046804437 |
RPL14 | 2 | ENSG00000213486 | 61,710,076 | 61,710,978 | 3.575564399 | 0.000349473 | 0.046804437 |
TACC3 | 4 | ENSG00000013810 | 1,712,858 | 1,745,171 | 6.908777281 | 0.000375963 | 0.048615968 |