Table 2 Comparison of laboratory tests between clinically cured and poor prognosis groups of influenza-associated encephalopathy.
Variable (s) | Total (n = 56) | Clinical cure group (n = 30) | Poor prognosis group (n = 26) | P-value |
|---|---|---|---|---|
White blood cell count, 109/L, median (Q1, Q3) | 6.27 (4.22, 8.57) | 5.13 (3.89, 7.27) | 7.10 (5.32, 10.32) | 0.087 |
Neutrophil count, 109/L, median (Q1, Q3) | 4.14 (2.01, 7.29) | 3.54 (1.91, 5.69) | 5.72 (2.74, 9.28) | 0.085 |
Lymphocyte count, 109/L, median (Q1, Q3) | 1.44 (0.80, 2.66) | 1.77 (1.12, 2.93) | 1.29 (0.76, 2.18) | 0.121 |
Hemoglobin, g/L, mean ± SD | 111.54 ± 15.90 | 112.17 ± 13.38 | 110.81 ± 18.64 | 0.759 |
Platelet count, 109/L, mean ± SD | 233.80 ± 142.87 | 254.13 ± 128.52 | 210.35 ± 157.09 | 0.264 |
High-sensitivity C-reactive protein, mg/L, Median (Q1, Q3) | 4.78 (0.84, 8.38) | 1.88 (0.84, 6.37) | 6.80 (2.18, 14.72) | 0.003 |
Interleukin-6, pg/mL, median (Q1, Q3) | 10.70 (5.14, 32.06) | 8.24 (4.14, 10.70) | 20.26 (7.65, 280.24) | 0.001 |
Interleukin-10, pg/mL, median (Q1, Q3) | 5.21 (2.80, 11.00) | 4.72 (2.78, 5.21) | 11.75 (3.86, 34.76) | 0.003 |
Serum ferritin, ng/mL, median (Q1, Q3) | 230.80 (107.32, 428.91) | 230.80 (104.47, 294.80) | 245.51 (193.80, 3266.57) | 0.054 |
Alanine aminotransferase, U/L, median (Q1, Q3) | 24.0 (15.0, 128.8) | 20.0 (15.0, 34.8) | 104.0 (15.8, 519.3) | 0.011 |
Aspartate aminotransferase, U/L, median (Q1, Q3) | 47.0 (28.0, 237.8) | 37.0 (28.0, 50.3) | 186.5 (40.0, 581.0) | 0.003 |
Serum total protein, g/L, mean ± SD | 70.12 ± 10.28 | 70.55 ± 9.06 | 69.63 ± 11.70 | 0.747 |
Serum albumin, g/L, mean ± SD | 39.47 ± 4.99 | 40.76 ± 4.24 | 37.99 ± 5.45 | 0.042 |
Serum globulin, g/L, mean ± SD | 29.61 ± 10.21 | 29.30 ± 9.51 | 29.97 ± 11.13 | 0.812 |
Serum urea nitrogen, mmol/L, median (Q1, Q3) | 4.0 (2.7, 5.6) | 3.8 (2.8, 4.5) | 4.9 (2.7, 7.3) | 0.194 |
Serum creatinine, µmol/L, median (Q1, Q3) | 32.1 (27.3, 38.6) | 29.9 (27.3, 35.3) | 34.6 (26.7, 47.3) | 0.148 |
Serum sodium ion, mmol/L, median (Q1, Q3) | 137.40 (134.70, 139.60) | 137.35 (135.35, 139.25) | 137.45 (133.22, 139.73) | 0.755 |
Serum potassium ion, mmol/L, mean ± SD | 4.19 ± 0.51 | 4.15 ± 0.46 | 4.25 ± 0.57 | 0.489 |
Serum calcium ion, mmol/L, median (Q1, Q3) | 2.27 (2.19, 2.36) | 2.30 (2.22, 2.37) | 2.24 (2.10, 2.34) | 0.095 |
Serum chloride ion, mmol/L, median (Q1, Q3) | 104.10 (100.77, 106.70) | 104.10 (102.15, 105.55) | 104.00 (100.45, 108.35) | 0.928 |
Prothrombin time, seconds, median (Q1, Q3) | 11.5 (10.8, 14.2) | 11.4 (10.7, 12.2) | 13.2 (10.9, 17.4) | 0.017 |
Fibrinogen, g/L, mean ± SD | 2.26 ± 0.79 | 2.33 ± 0.75 | 2.18 ± 0.83 | 0.472 |
D-dimer, mg/L FEU, median (Q1, Q3) | 0.78 (0.35, 3.78) | 0.44 (0.33, 0.79) | 4.34 (0.78, 14.57) | < 0.001 |
CD3 T-cell count, cells/µL, median (Q1, Q3) | 731.00 (507.25, 990.05) | 731.00 (666.75, 1023.50) | 713.50 (313.25, 897.00) | 0.155 |
CD4 T-cell count, cells/µL, median (Q1, Q3) | 129.00 (62.75, 250.00) | 129.00 (74.25, 419.25) | 90.00 (55.75, 143.75) | 0.124 |
CD8 T-cell count, cells/µL, mean ± SD | 2.46 ± 0.62 | 2.43 ± 0.88 | 2.50 ± 0.88 | 0.958 |
CD19 B-cell count, cells/µL, median (Q1, Q3) | 33.37 (25.77, 37.05) | 32.75 (24.67, 33.37) | 35.11 (28.01, 43.60) | 0.018 |
Natural killer cell, cells/µL, median (Q1, Q3) | 130.50 (88.00, 238.50) | 130.50 (96.50, 289.00) | 130.50 (73.00, 222.75) | 0.469 |
Cerebrospinal fluid cell count, 106/L, median (Q1, Q3) | 4 (2, 6) | 3 (2, 6) | 4 (1, 6) | 0.882 |
Cerebrospinal fluid protein, g/L, median (Q1, Q3) | 0.18 (0.16, 0.22) | 0.18 (0.15, 0.24) | 0.18 (0.18, 0.18) | 0.751 |
Cerebrospinal fluid glucose, mmol/L, median (Q1, Q3) | 3.75 (3.71, 3.77) | 3.75 (3.41, 3.89) | 3.75 (3.75, 3.75) | 0.269 |
Cerebrospinal fluid chloride, mmol/L, mean ± SD | 126.11 ± 3.48 | 125.50 ± 4.19 | 126.82 ± 2.30 | 0.027 |
