Table 4 Parameter levels and ranges in Box-Behnken Experimental Design.

From: Preparation of curcumin submicron particles by supercritical antisolvent method with external adjustable annular gap nozzle

Factors

Symbols

Range and level

− 1

1

Crystallizer pressure (MPa)

A

12

16

Crystallizer temperature (K)

B

313

323

Solution concentration (mg/mL)

C

1

2

Flow ratio of CO2/Solution (g/g)

D

133

173

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