Table 3 Multivariate Cox regression analyses of survival in patients with PCNSL.

From: Association between surgery and increased survival in primary central nervous system lymphoma: a retrospective cohort study

Characteristic

Crude model

Model 1

Model 2

Model 3

HR (95%CI)

p-Value

HR (95%CI)

p-Value

HR (95%CI)

p-Value

HR (95%CI)

p-Value

OS

 Non-surgery

1 (reference)

 

1 (reference)

 

1 (reference)

 

1 (reference)

 

 STR

0.79 (0.72 ~ 0.88)

 < 0.001

0.79 (0.72 ~ 0.87)

 < 0.001

0.79 (0.72 ~ 0.88)

 < 0.001

0.77 (0.70 ~ 0.85)

 < 0.001

 GTR

0.76 (0.68 ~ 0.84)

 < 0.001

0.76 (0.69 ~ 0.85)

 < 0.001

0.76 (0.69 ~ 0.85)

 < 0.001

0.73 (0.65 ~ 0.80)

 < 0.001

CSS

 Non-surgery

1 (reference)

 

1 (reference)

 

1 (reference)

 

1 (reference)

 

 STR

0.76 (0.68 ~ 0.85)

 < 0.001

0.76 (0.68 ~ 0.84)

 < 0.001

0.76 (0.68 ~ 0.85)

 < 0.001

0.74 (0.66 ~ 0.83)

 < 0.001

 GTR

0.76 (0.68 ~ 0.85)

 < 0.001

0.77 (0.68 ~ 0.86)

 < 0.001

0.77 (0.68 ~ 0.86)

 < 0.001

0.73 (0.65 ~ 0.82)

 < 0.001

  1. PCNSL primary central nervous system lymphoma, OS overall survival, CSS cancer-specific survival, HR hazard ratio, CI confidence interval, STR subtotal resection, GTR gross total resection.
  2. Model 1: Adjusted for variables (age, sex, race, marital status, median household income); Model 2: Adjusted for Model 1 and years of diagnosis, primary site, histologic subtype, laterality, time from diagnosis to treatment, rural urban continuum; Model 3: Adjusted for Model 2 and radiation, chemotherapy.
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