Fig. 4

Representation of nonlinear regression with the log inhibitor vs. normalized response, with the Hill slope set to -1.0 for in vitro combination experiments. Inhibition was measured for B5 at decreasing doses (0.3, 0.1, 0.033 µM) while Elt was kept constant at 7.5 µM; for Elt at decreasing doses (7.5, 2.5, 0.8 µM) while B5 was kept constant at 0.3 µM; for B22 at decreasing doses (13.7, 4.6, 1.5 µM) while Elt was kept constant at 7.5 µM; for Elt at decreasing doses (7.5, 2.5, 0.8 µM) while B22 was kept constant at 13.7 µM; for Cnd at decreasing doses (15.6, 5.2, 1.7 µM) while Elt was kept constant at 7.5 µM; and for Elt at decreasing doses (7.5, 2.5, 0.8 µM) while Cnd was kept constant at 15.6 µM.