Fig. 6
(A) Effect of selected molecules in combination on the replication of SARS-CoV-2 replicon in Caco-2 cell lines. Luciferase readings were normalized to the control group (DMSO) and set as 100. Cells that were not transfected with the SARS-CoV-2 replicon was named as Untreated group. Statistical significance was calculated for each condition compared to the control group using one-way ANOVA (non-parametric) test. Data represent mean and the standard error of the mean ± SEM, n = 4–5 (*p < 0.05; **p < 0.01; ***p < 0.0005; ****p < 0.0001). (B) The inhibitory effects of molecular combinations were depicted as a heatmap. Values within the boxes represent replication level of SARS-CoV-2 replicon in Caco-2 cell line, where darker colors with lower numbers indicate higher inhibition, and lighter colors with higher numbers indicate lower inhibition. A value of 100 on the heatmap corresponds to the replication in the control group (DMSO). (C) Effect of selected molecules in combination on the replication of SARS-CoV-2 replicon in Calu-3 cell lines. Luciferase readings were normalized to the control group (DMSO) and set as 100. Cells that were not transfected with the SARS-CoV-2 replicon were named as Untreated group. Statistical significance was calculated for each condition compared to the control group using one-way ANOVA (non-parametric) test. Data represent mean and the standard error of the mean ± SEM, n = 4–5 (*p < 0.05; **p < 0.01; ***p < 0.0005). (D) The inhibitory effects of molecular combinations were depicted as a heatmap. Values within the boxes represent replication level of SARS-CoV-2 replicon in Calu-3 cell line, where darker colors with lower numbers indicate higher inhibition, and lighter colors with higher numbers indicate lower inhibition. A value of 100 on the heatmap corresponds to the replication in the control group (DMSO).
