Table 1 MR estimates were calculated for the mediation effect involving TSH and FT4.

From: The mediating role of thyroid-related hormones between thyroid dysfunction diseases and osteoporosis: a mediation mendelian randomization study

Mediator

Direct effect β1

(95% CI)

Direct effect β2

(95% CI)

Total effect β3

(95% CI)

Mediation effect β

Mediated

Proportion(%)

FT4

0.034

(0.013,0.056)

0.219

(0.037,0.402)

0.077

(0.026,0.128)

0.007

9.670

TSH

0.124

(0.022,0.226)

0.072

(0.003,0.141)

0.168

(0.118,0.218)

0.009

5.314

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