Fig. 3
From: Novel cisplatin-magnetoliposome complex shows enhanced antitumor activity via Hyperthermia
Transmission electron microscopy of ML-treated cell lines. LL2 (Panel A) and Panc02 (Panel B) cell lines were incubated for 4 h with 200 µg of blank liposomes (2nd from left, top row); blank magnetoliposome without (3rd from left, top row) or after 10 min of magnetic hyperthermia (first from left, bottom row); or CDDP-encapsulated ML without (second from left, bottom row) or after magnetic hyperthermia (third from left, bottom row). Untreated cells are shown in the upper first panel from left. Representative images from two independent experiments were selected by blind observers. Cells were immediately collected and processed as indicated in Materials and Methods. UT: Untreated cells; L: blank liposome; ML: blank magnetoliposome (liposome + magnetic nanoparticles); MLC: CDDP-encapsulated ML (liposome + nanoparticles + CDDP); MF: Magnetic field.
