Fig. 4

The mutation between two clusters. The mutational landscape of cluster 1 and cluster 2, respectively (A and B). The tumor mutation burden (TMB) etween two clusters (C). The association of POLE proofreading domain with mismatch repairing of gene mutation between two clusters (D). The number of cluster1 is 79, and cluster2 is 65. The data are mean ± standard deviation (**P < 0.01 compared with the corresponding control values).