Table 2 The potential aneurysmal subarachnoid haemorrhage (aSAH) risk factors analysed by traditional statistical methods.

From: Identifying novel risk factors for aneurysmal subarachnoid haemorrhage using machine learning

Potential risk factors

No aSAH

aSAH

Unadjusted OR (95% CI)

Adjusted* OR (95% CI)

Log(Peak expiratory flow), mean (SD)

5.87 (0.40)

5.77 (0.45)

0.60** (0.53–0.69)

0.80** (0.66–0.96)

Log(SHBG), mean (SD)

3.81 (0.51)

3.91 (0.51)

1.46** (1.26–1.69)

1.29** (1.09–1.53)

Log(C-reactive protein), mean (SD)

0.31 (1.04)

0.42 (1.03)

1.09** (1.02–1.17)

1.01 (0.94–1.08)

IGF-1, mean (SD)

21.37 (5.58)

20.70 (5.64)

0.98** (0.97–0.99)

1.00 (0.98–1.01)

Mean sphered cell volume, mean (SD)

82.79 (5.14)

83.52 (5.17)

1.03** (1.01–1.04)

1.02** (1.00–1.03)

Sitting height, mean (SD)

89.15 (4.88)

88.26 (4.86)

0.96** (0.95–0.97)

0.99 (0.97–1.01)

Hand grip strength, mean (SD)

30.61 (11.03)

28.60 (11.17)

0.98** (0.98–0.99)

1.00 (0.99–1.01)

Log(Forced vital capacity), mean (SD)

1.26 (0.29)

1.19 (0.31)

0.51** (0.42–0.62)

0.92 (0.68–1.25)

Glycated haemoglobin (HbA1c), mean (SD)

35.49 (4.50)

35.74 (4.30)

1.01 (1.00–1.02)

0.99 (0.97–1.00)

Haematocrit percentage, mean (SD)

41.08 (3.54)

40.63 (3.35)

0.96** (0.95–0.98)

0.97** (0.95–1.00)

Urea, mean (SD)

5.37 (1.28)

5.47 (1.37)

1.06** (1.00–1.11)

1.04 (0.99–1.10)

Number of self-reported non-cancer illnesses, mean (SD)

1.86 (1.87)

2.16 (2.26)

1.08** (1.05–1.11)

1.03 (1.00–1.07)

Systolic blood pressure, mean (SD)

137.81 (18.68)

140.25 (18.62)

1.01** (1.00–1.01)

1.00 (1.00–1.01)

Townsend deprivation index at recruitment, mean (SD)

−1.29 (3.09)

−1.15 (3.16)

1.01 (0.99–1.04)

1.00 (0.98–1.02)

Body mass index (BMI), mean (SD)

27.43 (4.80)

26.94 (4.79)

0.98** (0.96–0.99)

0.97** (0.96–0.99)

Log(Creatinine (enzymatic) in urine), mean (SD)

8.88 (0.68)

8.83 (0.68)

0.91 (0.82–1.00)

1.01 (0.91–1.12)

Impedance of leg, mean (SD)

247.36 (35.27)

252.11 (36.28)

1.00** (1.00–1.01)

1.00** (1.00–1.01)

Lymphocyte count, mean (SD)

1.94 (0.60)

1.97 (0.65)

1.08 (0.97–1.21)

0.94 (0.84–1.05)

Tea intake, mean (SD)

3.41 (2.90)

3.72 (3.36)

1.03** (1.01–1.05)

1.03** (1.01–1.05)

Neutrophil percentage, mean (SD)

60.88 (8.52)

60.89 (9.21)

1.00 (0.99–1.01)

1.00 (0.99–1.01)

  1. All odds ratios for numerical variables indicate the increased aSAH risk associated with a 1 standard deviation increase of that variable. *: Adjusted for age at baseline, female sex, hypertension, smoking status, and alcohol use. **: Statistically significant at a threshold of p < 0.05 (indicated in bold). OR = Odds-ratio, CI = Confidence interval, SD = Standard deviation, SHBG = Sex hormone binding globulin, IGF-1 = Insulin-like growth factor 1.