Table 2 Number of hydrogen bonds formed by C4 and C5 with Wnt3a, Notch1 and shh.

From: Exploring the cytotoxic effects of bioactive compounds from Alcea rosea against stem cell driven colon carcinogenesis

Drugs

Proteins

Wnt3a

Notch1

Shh

Compound 4

Chain A = 5 (Gln75, Gln78, Cys88, and Thr90)

Chain A = 5 (Arg176, Gln177 and Asp178)

Chain H = 6 (Lys45, Glu53, Ser135, Tyr174, Glu176 and His182)

Compound 5

Chain A = 5 (Arg82, Thr296, Asp305 and Cys307)

Chain A = 6 (Cys182, Lys185, Gly187, Cys189 and Gly193)

Chain H = 6 (Glu89, Arg123, Asp147, Arg153 and Ala179)

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