Table 3 The hazard ratio of the duration of using metformin and sulfonylurea on all-cause mortality.

From: Medication time of metformin and sulfonylureas and incidence of cardiovascular diseases and mortality in type 2 diabetes: a pooled cohort analysis

Model

Exposure (Medication time in years)

Cox model

Hazard ratio adjusted

95% CI

P value

1

Metformin

0.90

0.87,0.94

0.001

Sulfonylurea

0.93

0.89,0.98

0.044

Sulfonylurea + Metformin

0.89

0.83,0.94

0.001

2

Metformin

0.91

0.85,0.98

0.006

Sulfonylurea

0.94

0.88,1.01

0.066

Sulfonylurea + Metformin

0.88

0.80,0.96

0.001

3

Metformin

0.96

0.94,0.98

0.006

Sulfonylurea

0.97

0.95,0.99

0.045

Sulfonylurea + Metformin

0.95

0.92,0.98

0.001

Hypertension medication

0.95

0.91,0.99

0.009

Statin

0.94

0.91,0.98

0.001

aspirin

0.93

0.89,0.98

0.001

  1. Model 1: Crude.
  2. Model 2: Adjusted for Mean of age and Mean of FBS at follow-up.
  3. Model 3: Adjusted for Mean of age, FBS, HDL, LDL, TG, waist, Physical activity, Statin use, aspirin use, Hypertension medication, Educational level, creatinine, Sex, smoking and Systolic and diastolic blood pressure (mmHg) at follow-up period.
  4. CPH model was used in model 1, 2 and 3.
  5. Fine-Gray model was used to estimate the competing risk effect.
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