Table 3 Ashcroft scoring.

From: The role of oxidative stress-related genes in idiopathic pulmonary fibrosis

Fibrosis score

Alveolar septa

Lung structure

0

No fibrosis

Normal

1

Isolated, mild fibrous changes (septal thickness ≤ 3 × normal)

Partially enlarged and loose alveoli; no fibrotic masses

2

Obvious fibrous changes (septal thickness > 3 × normal), nodular, but not connected to other septa

Partially enlarged and loose alveoli; no fibrotic masses

3

Continuous fibrous alveolar walls (septal thickness > 3 × normal), occupying the majority of the microscopic field

Partially enlarged and loose alveoli; no fibrotic masses

4

Distorted

Single fibrotic mass (≤ 10% of microscopic field)

5

Distorted

Confluent fibrotic masses (10% < microscopic field ≤ 50%)

6

Distorted, mostly absent

Large, continuous fibrotic masses (> 50% of microscopic field); lung architecture mostly absent

7

Absent

Alveoli almost completely absent, with fibrotic masses present, but up to 5 airspaces remain

8

Absent

Fibrotic mass, complete obliteration