Fig. 1 | Scientific Reports

Fig. 1

From: Chlorogenic acid inhibits Pseudomonas toxin pyocyanin and activates mitochondrial UPR to protect host against pathogen infection

Fig. 1

Chlorogenic acid promotes innate immunity in C. elegans. (A) CGA promoted innate immunity in dose-dependent manner. (*P < 0.05, log-rank test). See Table S1 for survival data. (B) Survival of N2 animals exposed to heat-killed P. aeruginosa PA14 after CGA treatment. (*P < 0.05; log-rank test). See Table S1 for survival data. (C) 100 µM CGA significantly inhibited the proliferation of P. aeruginosa PA14. (*P < 0.05, log-rank test). Error bars represent mean ± SEM of three independent biological replicates. (D) 100 µM CGA decreased the intestinal bacteria burden in WT worms after P. aeruginosa PA14 infection 48 h. (n ≥ 20). These results are mean ± SEM of three independent experiments. (*P < 0.05, unpaired t-test).

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