Fig. 5 | Scientific Reports

Fig. 5

From: Chlorogenic acid inhibits Pseudomonas toxin pyocyanin and activates mitochondrial UPR to protect host against pathogen infection

Fig. 5

Chlorogenic acid protects mice from P. aeruginosa PA14 infection. (A) CGA treatment (50 mg/kg body weight) enhanced resistance to P. aeruginosa PA14 infection in wild-type mice. (*P < 0.05, log-rank test). (B) The CFUs of P. aeruginosa from lung homogenates plated on LB agar plates after CGA treatment. (C)

CGA increased the mRNA levels of mouse UPRmt genes HSPD1, HSPA9, LONP1, and YME1L1 in lung tissue. These results are mean ± SEM of three independent experiments performed in triplicate. (*P < 0.05, one-way ANOVA). (D) CGA increased the protein levels of ATF5 in lung tissue. The right panel shows quantification of ATF5. These results are mean ± SEM of three independent experiments performed in triplicate. (*P < 0.05, one-way ANOVA).

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