Fig. 1 | Scientific Reports

Fig. 1

From: The MEK inhibitor trametinib is effective in inhibiting the growth of canine oral squamous cell carcinoma

Fig. 1

PDX Model Characterization. Representative 10X light photomicrograph images of formalin-fixed and paraffin-embedded samples taken from three primary COSCCs corresponding to the (A) basaloid (bOSCC; tumor 270,858,), (B) conventional (cOSCC; tumor 294,246) and (C) papillary (pOSCC, tumor 301,313) histological subtypes, and corresponding patient-derived xenograft (PDX) samples. Except for sample 270_PDX301 (P3) (panel A), which corresponded to a murine tumor that formed at the implantation site upon second passage, note the consistent neoplastic epithelial cell (arrows) invasion of the mesenchymal stroma (asterisks) in the primary tumor and PDX samples observed on hematoxylin and eosin (H&E) and pan-cytokeratin stains. Also, scattered Ki67 nuclear immunoreactivity of proliferating neoplastic epithelial cells (arrows) in the primary tumor samples is similar to the corresponding PDX samples.

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