Table 1 Characterization of tumors used to derive model systems.

Cell Line	Tumor	Age (yrs)	Sex	Breed	Tumor location	Diagnosis	BRAF p.V595E status	BRAF p.V595E status (cell line)
Co-B-658	270,858	10	Female spayed	Dachshund	Rostral maxilla	bOSCC	WT	n/a	PDX
Co–C-958	270,858	10	Female spayed	Dachshund	Rostral maxilla	bOSCC	WT	n/a	PDX
Co-F-1236	294,236	7	Male castrated	Alaskan malamute	Caudal mandible	cOSCC	WT	WT	PDX
Co-L-1236	294,236	7	Male castrated	Alaskan malamute	Caudal mandible	cOSCC	WT	WT	PDX
Co-G-1114	301,814	11	Male castrated	Miniature poodle	Caudal mandible	cOSCC	WT	WT	PDX
Co–N-1242	322,742	10	Female spayed	Yorkshire terrier	Caudal maxilla	pOSCC	WT	WT	Primary tumor
Co-I-913	301,313	4	Female spayed	Labradoodle	Caudal maxilla	pOSCC	V595E	V595E	PDX
Co-J-1220	303,520	6	Female spayed	Labrador retriever	Caudal maxilla	pOSCC	V595E	n/a	PDX
Co–O-172	324,672	2	Female spayed	Labrador retriever	Rostral maxilla	pOSCC	V595E	V595E	Primary tumor

BRAF status is reported as wild type (WT), the specific mutant determined, or ‘n/a’ for cell lines found to be murine rather than canine. Diagnosis is the histological subtype, either basaloid (b), conventional (c), or papillary (p) OSCC.

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