Table 2 Suggestive associations identified by comparing the class with the highest pain impairment (class 5; severe pain trajectory) to the class reporting no pain impairment over time (class 1). The results from the genome-wide association study (\(p<2\times{10}^{-6}\)) comparing participants assigned to the two most extreme pain trajectory classes (class 1 [reference] and class 5), adjusting for age, sex, and the first three multi-dimensional scaling (MDS) components. Abbreviations: OR: odds ratio; MAF: minor allele frequency; CI: confidence interval. *Genes within +/-25 kilobases (kb).
From: Exploring the early drivers of pain in Parkinson’s disease
Chromosome | Base pair position (hg38) | SNP | Risk allele | MAF | OR (95% CI) | p-value | Nearest Gene* |
|---|---|---|---|---|---|---|---|
6 | 130,562,453 | rs117108018 | C | 0.013 | 8.96 (3.89, 20.61) | \(2.53\times{10}^{-7}\) | Y_RNA (< 12 kb 5’) |
10 | 48,354,205 | rs72794357 | A | 0.035 | 4.61 (2.49, 8.54) | \(1.21\times{10}^{-6}\) | MAPK8 (intronic) |
9 | 2,657,752 | rs4741753 | G | 0.314 | 2.24 (1.62, 3.10) | \(1.24\times{10}^{-6}\) | VLDLR (3’ UTR) |
2 | 140,207,013 | rs4954824 | A | 0.260 | 2.21 (1.60, 3.05) | \(1.73\times{10}^{-6}\) | AC092156.3 (< 10 kb) LRP1B (< 25 kb 3’) |
2 | 140,193,047 | rs964037 | A | 0.260 | 2.20 (1.59, 3.05) | \(1.77\times{10}^{-6}\) | AC092156.3 (< 24 kb) |
9 | 73,741,640 | rs77599163 | T | 0.028 | 4.82 (2.53, 9.20) | \(1.78\times{10}^{-6}\) | RNA5SP286 (< 10 kb) |
12 | 115,348,208 | rs11067544 | A | 0.058 | 3.26 (2.01, 4.76) | \(1.95\times{10}^{-6}\) | RP11-116D17.1 (< 15 kb) |
