Table 3 Suggestive associations identified by comparing increasing pain trajectory classes (classes 2–5; C2-5) to the no pain over time trajectory (class 1; C1). The results from the genome-wide multinomial logistic regression analysis (\(p<2\times{10}^{-6}\)) comparing subjects assigned to the four trajectories of increased pain over time (classes 2–5; C2-5) to subjects reporting no pain over time (class 1; C1), adjusting for age, sex, and the first three multi-dimensional scaling (MDS) components. Abbreviations: OR: odds ratio; MAF: minor allele frequency; CI: confidence interval; C1–C5: class 1 (no pain over time) to class 5 (severe pain over time). *Genes within +/-25 kilobases (kb).
From: Exploring the early drivers of pain in Parkinson’s disease
Chromosome | Base pair position (hg38) | SNP | Risk allele | MAF | C2 vs. C1 OR (95% CI) | C3 vs. C1 OR (95% CI) | C4 vs. C1 OR (95% CI) | C5 vs. C1 OR (95% CI) | p-value | Nearest Gene* |
|---|---|---|---|---|---|---|---|---|---|---|
11 | 36,234,620 | rs61881484 | T | 0.078 | 1.00 (0.80, 1.25) | 0.95 (0.73, 1.25) | 1.73 (1.35, 2.22) | 0.44 (0.19, 1.03) | \(1.96\times{10}^{-7}\) | LDLRAD3 (< 2.5 kb 5’) |
3 | 134,281,183 | rs9859176 | T | 0.399 | 1.05 (0.93, 1.19) | 1.18 (1.02, 1.36) | 1.49 (1.29, 1.73) | 1.26 (0.93, 1.72) | \(3.28\times{10}^{-7}\) | |
3 | 134,011,416 | rs7653639 | T | 0.184 | 1.17 (1.00, 1.36) | 0.82 (0.678, 0.99) | 0.77 (0.63, 0.94) | 1.26 (0.86, 1.83) | \(1.49\times{10}^{-6}\) | SLCO2A1 (intronic) |
3 | 134,217,925 | rs9839609 | T | 0.389 | 1.06 (0.94, 1.20) | 1.19 (1.03, 1.38) | 1.46 (1.27, 1.70) | 1.22 (0.90, 1.67) | \(1.73\times{10}^{-6}\) | RYK (intronic) |
3 | 134,222,660 | rs9865808 | A | 0.389 | 1.06 (0.94, 1.20) | 1.19 (1.03, 1.38) | 1.47 (1.27, 1.70) | 1.22 (0.90, 1.67) | \(1.94\times{10}^{-6}\) | RYK (intronic) |
11 | 36,232,669 | rs11606598 | C | 0.074 | 1.00 (0.80, 1.26) | 0.96 (0.73, 1.26) | 1.68 (1.31, 2.16) | 0.46 (0.20, 1.06) | \(1.99\times{10}^{-6}\) | LDLRAD3 (< 0.5 kb 5’) |
