Fig. 6

Functionally relevant changes (changes exceeding ± 10% BW) as result of kinematic variations in medial (MED) compartment knee contact forces and relative changes in lateral (LAT) compartment (relevant changes are depicted with filled red and blue circle) expressed as a % difference in body weight (BW) compared to knee contact forces estimated using the mean knee OA gait pattern (black dotted lines), at the top. Solid grey lines are the cut-off/threshold for functionally relevant knee contact force changes (see Material and Methods section “Methods”). Dotted grey lines define peak 1 (P1) and peak 2 (P2) of the gait cycle. Below (bottom) are the kinematics of the different joints contributing to the top 50% (see Fig. 4) of the observed variation for each specific mode depicted as ± 1 STD (red, blue respectively). Grey dashed line defines the stance phase.