Fig. 6 | Scientific Reports

Fig. 6

From: Aloe polysaccharide promotes keratinocyte proliferation, migration, and differentiation by upregulating the EGFR/PKC-dependent signaling pathways

Fig. 6

ACE induces keratinocyte differentiation through activation of PKC and EGFR. (A) Cells were treated with ACE (3 mg/ml), PMA (100 nM), and EGF (50 ng/ml) for 6, 12, 18, and 24 h, respectively. (B) Alternatively, cells were treated with ACE, PMA, and osimertinib for 24 and 36 h. The expressions of differentiation markers including involucrin, loricrin, and TGase 1 were determined. The relative protein expression level was normalized by β-actin. The line charts representing quantifications of protein expression levels in each panel were shown in Figure S7.

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