Fig. 7 | Scientific Reports

Fig. 7

From: Aloe polysaccharide promotes keratinocyte proliferation, migration, and differentiation by upregulating the EGFR/PKC-dependent signaling pathways

Fig. 7

Effects of PKC and EGFR inhibitors on ACE-induced proliferation and migration of HaCaT cells. (A) Cells were starved for 24 h and then cultured with fresh DMEM containing 10% FBS and the indicated agents including PMA (100 nM), ACE (3 mg/ml), Ro320432 (30 µM), and osimertinib (1 µM). The cell number was counted every 24 h. * p < 0.05 compared to vehicle-treated cells at the same migration time. # p < 0.05 compared to Ro320432-treated cells at the same migration time. (B) The effects of PMA, Ro320432, EGF, and osimertinib on ACE-induced migration of HaCaT cells. The gap recovery area was quantified using Image J software (right panel). * p < 0.05 compared to vehicle-treated cells at 0 h migration time. # p < 0.05 compared to ACE-treated cells.

Back to article page