Fig. 2 | Scientific Reports

Fig. 2

From: Causal interaction of metabolic oscillations in monolayers of HeLa cervical cancer cells: emergence of complex networks

Fig. 2

Causality of oscillations between all pairs of two cells in the monolayers analyzed by Convergent Cross Mapping (CCM). (A) Causality of oscillations between all pairs of two cells at their intercellular distance \(\:d\) from 10 \(\:{\upmu\:}\text{m}\) to 500 \(\:{\upmu\:}\text{m}\) was analyzed. (B) distribution of CCM values larger than 0.8, \(\:{N}_{\text{C}\text{C}\text{M}\:0.8}\), within the intercellular distance between \(\:d\) and \(\:d+5\) \(\:\mu\:m\). (C) Distribution of number of cell-pairs, \(\:{N}_{\text{p}\text{a}\text{i}\text{r}\text{s}}\). (D) ratio, \(\:{r}_{\text{C}\text{C}\text{M}\:0.8}\), (\(\:={N}_{\text{C}\text{C}\text{M}\:0.8}/{N}_{\text{p}\text{a}\text{i}\text{r}\text{s}}\)) of the number of CCM values to the number of cell-pairs as a function of \(\:d\). The number of analyzed pair of cells was 254C2 = 32,131.

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