Table 1 Characteristics of patients according to tolerance to inhaled antibiotics.

From: Tolerance and effectiveness of inhaled antibiotics at standard or low doses in COPD patients with chronic Pseudomonas aeruginosa bronchial infection

 

Total

n = 87

Tolerance to IA

n = 40 (46%)

Intolerance to IA

n = 47 (54%)

P value

Sociodemographic

    

Gender, (% of men)

98.9

100

97.9

1.000

Age

75.7 (7.8)

74.9 (7.6)

76.4 (8.1)

0.401

Smoking habit, packs- year

62.9 (29)

59.1 (27.2)

66.2 (30.5)

0.288

Currently smoking, (%)

5.8

7.5

4.3

0.853

Charlson comorbidity index

5.6 (2)

5.7 (1.9)

5.5 (2.1)

0.601

Symptoms

    

Daily expectoration, (%)

87.4

85

89.4

0.775

Type expectoration (n = 76)

    

White, (%)

30.3

32.4

28.6%

 

Mucopurulent, (%)

60.5

58.8%

61.9%

0.760

Purulent, (%)

9.2

8.8%

9.5%

 

Dyspnoea (mMRC)

2.3 (0.9)

2.2 (0.9)

2.5 (0.9)

0.084

Respiratory function

    

FVC postBD %

68.2 (18.8)

71.5 (16)

65.5 (20.7)

0.061

FEV1 postBD %

46.4 (19.5)

51.5 (18)

42.1 (19.8)

0.002

Oxygen saturation %

94.2 (2.5)

94.7 (2.2)

93.8 (2.7)

0.072

Thorax CT scan

    

Emphysema, (%)

60.9

62.5

59.6

0.163

Bronchiectasis, (%)

63.2

65

61.7

0.163

Analytical data

    

Eosinophils cel/µl

229.3 (151.7)

235.1 (156.4)

224.5 (149.3)

0.825

Microbiological data

    

Number of PA isolation per patient the previous year

3.1 (1.3)

3.1 (1.1)

3.2 (1.4)

0.504

Exacerbations previous year

    

Ambulatory

3.3 (2.2)

3.1 (1.8)

3.5 (2.5)

0.561

Hospital admissions

1.7 (2)

1.6 (1.7)

1.8 (2.1)

0.488

Days of hospitalization

25.3 (18.3)

24 (15.5)

26.1 (20.3)

0.952

Treatments, (%)

    

LABA

100

100

100

1.000

LAMA

98.9

100

97.9

1.000

Inhaled corticosteroids

97.7

97,5

97.9

1.000

Long term azithromycin

91.9

95

89.4

0.570

Roflumilast

3.5

7.5

0

0.186

Long term oral corticosteroids

1.2

2.5

0

0.935

Oral cyclic antibiotics

3.5

0.0

6.4

0.300

Long term oxygen therapy

28.7

17.5

38.3

0.058

Inhaled antibiotic, (%)

    

Nebulized colistin

29.9

30

29.8

1.000

Dry powder colistin

5.8

5

6.4

1.000

Nebulized tobramycin

64.4

65

63.8

1.000

  1. Footnote: *Data presented as mean (SD) unless otherwise specified. IA: inhaled antibiotics; mMRC: modified Medical Research Council dyspnea scale; CT: computed tomography; FVC: forced vital capacity; FEV1: forced expiratory volume in 1 s; PA: Pseudomonas aeruginosa; LABA: long-acting beta-2 agonist; LAMA: long-acting anticholinergic.
Back to article page