Fig. 2

Analysis of the colon proteome at the experimental endpoint indicated changes in the blood coagulation-fibrinolytic system. (a) Results of the principal component analysis based on the colon proteome analysis of samples prepared after 5 days of DSS consumption. For proteomic analysis, four WT mice, three CGRPα KO mice and four CGRPβ KO mice were used. (b) Volcano plot showing comparison of protein levels between wild-type (WT) and CGRPα knockout (KO) mice. (c) Volcano plot showing comparison of protein levels between WT and CGRPβ KO mice. (d) Volcano plot showing comparison of protein levels between CGRPα KO and CGRPβ KO mice. (e) Gene set enrichment analysis (GSEA) results showing comparison of protein expression between WT and CGRPKα KO mice, with positive normalized enrichment score indicating higher expression in the CGRPα KO mice and negative normalized enrichment score indicating higher expression in the WT mice. (f) GSEA of protein expression between WT and CGRPβ KO mice, with positive normalized enrichment score terms indicating higher expression in CGRPβ KO mice and negative terms indicating higher expression in WT mice. (g) GSEA of protein expression between CGRPα KO and CGRPβ KO mice, with positive normalized enrichment score terms indicating higher expression in CGRPβ KO mice and negative terms indicating higher expression in CGRPα KO mice.