Fig. 5 | Scientific Reports

Fig. 5

From: Establishing metrics of clinically meaningful change for treating knee osteoarthritis with a combination of autologous orthobiologics

Fig. 5

Change in outcomes (ΔPROMs) for the ‘minimal improvement’ and ‘substantial improvement’ cohorts after receiving BMC and PRP treatment for knee OA. Patient reported SANE scores at 6- and 12-month follow-ups (a). Change in function (b-c) and pain (d) for those reporting minimal improvement (SANE = 15-45%, n = 45) and substantial improvement (SANE ≥ 60%, n = 166). Dotted lines specify SANE thresholds for improvement, dashed lines indicate no change, and solid lines represent means. Mean ΔPROMs of the minimal and substantial improvement cohorts (bold) represent a common, within cohort, approach for deriving an anchor-based MCID.

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