Table 3 Change in outcomes (ΔPROMs) for the ‘minimal improvement’ (SANE = 15-45%, n = 45) and substantial improvement (SANE ≥ 60%, n = 166) cohorts after receiving BMC and PRP treatment for knee OA. Values for 12-month ΔPROMs represent mean ± standard deviation. Anchor-based, within cohort MCID and SCB values (means of their respective patient cohorts), are displayed (bold) along with the number and percentage of patient knees meeting or exceeding them.

From: Establishing metrics of clinically meaningful change for treating knee osteoarthritis with a combination of autologous orthobiologics

ΔPROM

ΔIKDC

ΔLEFS

ΔNPS

‘Minimal’ (15% ≤ SANE ≤ 45%)

12.2 ± 11.5

8.4 ± 11.4

-1.8 ± 2.6

MCID

12.2

8.4

-1.8

Meet MCID? (n, %)

202, 68.5%

209, 70.8%

196, 66.4%

‘Substantial’ (60% ≤ SANE)

29.5 ± 15.5

22.5 ± 13.1

-3.0 ± 2.1

SCB

29.5

22.5

-3.0

Meet SCB? (n, %)

96, 32.5%

92, 31.2%

137, 46.4%

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