Table 3 Demographic data and clinical characteristics of candidemia patients.
Variables | Total; n (%) 489 (100%) | Pediatric patients (0–17 years); n (%) 71 (22.53%) | Adult patients (18–98 years); n (%) 418 (85.48%) | p-value |
|---|---|---|---|---|
Age (Median, range) | 63.5 years (1 day, 98 years) | 1 day (1 day,8 years) | 68 years (65 years, 98 years) | < 0.001 |
Male | 277 (56.6) | 43 (60.5) | 234 (55.9) | 0.47 |
Female | 212 (43.3) | 28 (39.4) | 184 (44.0) | 0.46 |
Underlying comorbidities (n, %) | ||||
Cardiovascular disease | 162 (33.1) | 5 (7.04) | 157 (37.5) | 0.001 |
Diabetes mellitus | 136 (27.8) | 6 (8.45) | 130 (31.1) | 0.001 |
Gastrointestinal pathology | 116 (23.7) | 2 (2.81) | 114 (27.2) | 0.001 |
Hematologic malignancy | 21 (4.29) | 3 (4.22) | 18 (4.30) | 0.98 |
Liver disease (acute or chronic) | 119 (24.3) | 11 (15.4) | 108 (25.8) | 0.06 |
Oral cavity | 60 (12.2) | 26 (36.6) | 34 (8.13) | 0.001 |
Renal failure | 48 (9.81) | 6 (8.45) | 42 (10.0) | 0.68 |
Respiratory dysfunction | 177 (36.1) | 17 (23.9) | 160 (38.2) | 0.02 |
Septic shock | 170 (34.7) | 24 (33.8) | 146 (34.9) | 0.001 |
Solid tumor | 18 (3.68) | 0 | 18 (4.30) | 0.07 |
Skin barrier | 38 (7.77) | 9 (12.6) | 29 (6.93) | 0.09 |
Surgery | 32 (6.54) | 6 (8.45) | 26 (6.22) | 0.48 |
Pulmonary diseases | 225 (46.0) | 25 (35.2) | 200 (47.8) | 0.05 |
Tuberculosis | 30 (6.13) | 5 (7.04) | 25 (5.98) | 0.73 |
Neurological diseases | 21 (4.29) | 5 (7.04) | 16 (3.82) | 0.22 |
UTI | 28 (5.72) | 2 (2.81) | 26 (6.22) | 0.25 |
Empirical Theraphy | ||||
Previous therapy with antibiotics | 228 (46.6) | 47 (23.9) | 181 (43.3) | 0.003 |
Treatment with antifungal agents | 159 (32.5) | 14 (19.7) | 142 (33.9) | 0.02 |
Indwelling devices | ||||
Central venous catheter | 81 (16.5) | 15 (21.2) | 48 (11.4) | 0.02 |
Urinary tract catheter | 167 (34.1) | 18 (25.3%) | 149 (35.6) | 0.09 |
Total parenteral nutrition | 47 (9.61) | 10 (14.0) | 37 (8.85) | 0.17 |
Mechanical ventilation | 119 (24.3) | 21 (29.5) | 98 (44.9) | 0.27 |
Other variable | ||||
ICU/PICU/NICU | 214 (43.7) | 41 (57.7) | 173 (79.3) | 0.01 |
Malnutrition | 60 (12.2) | 12 (16.9) | 48 (11.4) | 0.20 |
Laboratory findings | ||||
Anaemia | 146 (29.8) | 27 (38.0) | 119 (23.6) | 0.10 |
Thrombocytopaenia | 62 (12.7) | 15 (21.1) | 47 (11.2) | 0.02 |
Hyponatraemia | 150 (30.7) | 28 (39.4) | 122 (29.1) | 0.08 |
Hypernatremia | 30 (6.13) | 6 (8.45) | 24 (5.74) | 0.38 |
Mortality | ||||
7 days mortality | 27 (5.52) | 4 (5.63) | 23 (5.50) | 0.96 |
30 days mortality | 97 (19.8) | 6 (5.63) | 91 (21.7) | 0.009 |
All-cause mortality | 125 (25.5) | 10 (14.0) | 115 (27.5) | 0.07 |
