Table 4 Factors associated with 30-days mortality by univariate analysis in inpatients with candidaemia.
Variables | Child patients (0–17 years) 30 days outcome Survive Died n = 65 n = 6 | p-value | Adult Patients (18–98 years) 30 days outcome Survive Died n = 327 n = 91 | p-value | All patients 30-days outcome Survive Died n = 392 n = 97 | p-value | |||
|---|---|---|---|---|---|---|---|---|---|
Age (Median, range) | 1 day (1 day,8 years) | 1 day ( 1 day, 1 day) | 0.658 | 18 years (25 years, 98 years) | 29 year (38 years, 94 years) | 0.001 | 51 years (1 day, 98 years) | 64 years (1 day, 88 years) | 0.001 |
Male | 39 (60.0) | 4 (66.6) | 0.75 | 182 (55.6) | 52 (57.1) | 0.80 | 221 (56.3) | 56 (57.7) | 0.81 |
Female | 26 (40.0) | 2 (33.3) | 0.74 | 145 (44.3) | 39 (42.8) | 0.81 | 171 (43.6) | 41 (42.2) | 0.81 |
Underlying comorbidities (n, %) | |||||||||
Cardiovascular disease | 2 (3.07) | 0 | 0.66 | 32 (9.78) | 6 (6.59) | 0.35 | 34 (8.67) | 6 (6.18) | 0.42 |
Diabetes mellitus | 0 | 0 | - | 17 (5.19) | 2 (2.19) | 0.22 | 17 (4.33) | 2 (2.06) | 0.30 |
Gastrointestinal pathology | 2 (3.07) | 0 | 0.66 | 24 (7.33) | 6 (6.59) | 0.81 | 26 (6.63) | 6 (6.18) | 0.99 |
Hematologic malignancy | 0 | 0 | - | 12 (3.66) | 6 (6.59) | 0.22 | 12 (3.06) | 6 (6.18) | 0.14 |
Liver disease (acute or chronic) | 7 (10.7) | 0 | 0.40 | 30 (9.17) | 4 (4.39) | 0.13 | 37 (9.43) | 4 (4.12) | 0.09 |
Oral cavity | 3 (4.61) | 0 | 0.59 | 10 (3.05) | 0 | 0.09 | 13 (3.31) | 0 | 0.001 |
Respiratory dysfunction | 6 (9.23) | 4 (66.6) | 0.001 | 52 (15.9) | 27 (29.6) | < 0.001 | 58 (14.7) | 31 (31.9) | < 0.001 |
Septic shock | 15 (23.0) | 1 (16.6) | 0.72 | 98 (29.9) | 4 (4.39) | < 0.001 | 113 (28.8) | 5 (5.15) | < 0.001 |
Solid tumor | 10 (15.3) | 3 (50.0) | 0.04 | 8 (2.44) | 0 | 0.13 | 18 (4.59) | 3 (3.09) | 0.51 |
Surgery | 0 | 0 | - | 14 (4.28) | 4 (4.39) | 0.96 | 14 (14.7) | 4 (4.12) | 0.80 |
Pulmonary diseases | 17 (26.1) | 3 (50.0) | 0.21 | 50 (15.2) | 17 (18.6) | 0.44 | 67 (17.0) | 20 (20.6) | 0.21 |
Tuberculosis | 1 (1.53) | 0 | 0.76 | 24 (7.33) | 8 (8.79) | 0.65 | 25 (6.37) | 8 (8.24) | 0.51 |
Neurological diseases | 10 (15.3) | 2 (33.3) | 0.26 | 6 (1.83) | 2 (2.19) | 0.82 | 16 (4.08) | 4 (4.12) | 0.99 |
UTI | 2 (3.07) | 2 (33.3) | 0.002 | 12 (3.66) | 2 (2.19) | 0.49 | 14 (3.57) | 4 (4.12) | 0.79 |
Risk factors | |||||||||
Previous therapy with antibiotics | 65 (100) | 6 (100) | 0.99 | 103 (31.4) | 32 (35.1) | 0.51 | 168 (42.8) | 38 (39.1) | 0.51 |
Treatment with antifungal agents | 35 (53.8) | 6 (100) | 0.59 | 78 (23.8) | 24 (26.3) | 0.46 | 113 (28.8) | 30 (30.9) | 0.68 |
Central venous catheter | 2 (3.07) | 0 | 0.66 | 34 (10.3) | 16 (17.5) | 0.04 | 36 (9.18) | 16 (16.4) | 0.04 |
Urinary tract catheter | 4 (6.15) | 1 (16.6) | 0.34 | 108 (33.0) | 19 (20.8) | 0.03 | 112 (28.5) | 20 (20.6) | 0.11 |
Total parenteral nutrition | 1 (1.53) | 1 (16.6) | 0.03 | 28 (8.56) | 8 (8.79) | 0.95 | 29 (7.39) | 9 (9.27) | 0.54 |
ICU/PICU/NICU | 65 (100) | 6 (100) | > 0.99 | 64 (19.5) | 18 (19.7) | 0.96 | 129 (32.9) | 24 (24.7) | 0.96 |
Malnutrition | 14 (21.5) | 2 (33.3) | 0.51 | 28 (8.56) | 7 (7.69) | 0.79 | 42 (10.7) | 9 (9.27) | 0.71 |
Mechanical ventilation | 6 (9.23) | 2 (33.3) | 0.10 | 62 (18.9) | 32 (35.1) | 0.002 | 68 (17.3) | 34 (35.0) | 0.004 |
Laboratory findings | |||||||||
Anaemia | 11 (16.9) | 0 | 0.27 | 16 (4.89) | 2 (2.19) | 0.26 | 27 (6.88) | 2 (2.06) | 0.07 |
Thrombocytopaenia | 21 (32.3) | 1 (16.6) | 0.43 | 52 (15.9) | 6 (6.59) | 0.02 | 73 (18.6) | 7 (7.21) | 0.007 |
Renal failure | 5 (7.69) | 2 (33.3) | 0.04 | 20 (6.11) | 8 (8.79) | 0.37 | 25 (6.37) | 10 (10.3) | 0.18 |
Hyponatraemia | 7 (10.7) | 0 | 0.40 | 28 (8.56) | 7 (7.69) | 0.79 | 35 (8.92) | 7 (7.21) | 0.59 |
Hypernatremia | 11 (16.9) | 0 | 0.27 | 8 (2.44) | 0 | 0.13 | 19 (4.84) | 0 | 0.03 |
