Table 2 Logistic regression analysis for the risk predictors of SA-AKI.

Variables	Univariate logistic		Multivariate logistic1		Multivariate logistic2
Variables	OR [95%CI]	P	OR [95%CI]	P	OR [95%CI]	P
Clinical parameters
Age	0.99 [0.96–1.01]	0.290
APACHE	1.06 [1.00,1.13]	0.064
SOFA	1.22 [1.09,1.37]	0.001**	1.14 [1.01–1.29]	0.032*	1.07 [0.91–1.26]	0.442
Hypertension	1.80 [0.80,4.03]	0.157
Diabetes mellitus	1.50 [0.65,3.45]	0.343
Vasopressor	2.85 [1.21,6.70]	0.017*	1.15[0.35–3.67]	0.818	0.91 [0.22–3.70]	0.896
Nephrotoxic drugs	1.10 [0.35,3.43]	0.866
Diuretics	2.30 [0.96,5.55]	0.063
Sepsis shock	2.81 [1.23,6.45]	0.015*	1.45 [0.47–4.40]	0.507	1.12 [0.29–4.30]	0.867
Hospital death	1.64 [0.67,4.01]	0.279
Laboratory parameters
Scr	1.00 [0.99,1.02]	0.469
WBC	1.04 [0.98,1.09]	0.204
Neut	1.04 [0.99,1.11]	0.125
NLR	1.01 [1.00,1.02]	0.280
CRP	1.01 [1.00,1.02]	0.051
PCT	1.04 [1.01,1.07]	0.002**	1.03 [1.00-1.06]	0.039*	1.05 [1.01–1.09]	0.007**
BUN	1.10 [1.04,1.17]	0.001**	1.02 [0.94–1.12]	0.595	0.96 [0.85–1.07]	0.452
SUA	1.01 [1.00,1.01]	0.006**	1.01 [1.00-1.01]	0.006**	1.00 [0.99–1.01]	0.354
PLT	1.00 [1.00,1.00]	0.313
Fib	1.19 [0.97,1.46]	0.093
D-D	1.32 [1.04,1.68]	0.024*	1.14 [0.89–1.52]	0.334	1.19 [0.85–1.75]	0.342
FDP	1.01 [0.99,1.03]	0.200
Novel biomarkers
TIMP-2	1.04 [1.02,1.06]	0.000**
IGFBP-7	1.15 [1.07,1.24]	0.000**
TIMP-2×IGFBP-7	3.30 [1.91,5.70]	0.000**			2.71 [1.52–4.84]	0.001**
Ang-2	1.21 [1.10,1.33]	0.000**			1.19 [1.06–1.33]	0.004**

APACHE acute physiology and chronic health evaluation, SOFA sequential organ failure assessment, Scr serum creatinine, WBC white blood cell count, Neut neutrophils count, NLR neutrophil-to-lymphocyte ratio, PLT platelet, CRP C-reactive protein, PCT procalcitonin, BUN urea, SUA serum uric acid, Fib fibrinogen, D-D D-dimer, FDP Fibrin degradation products, TIMP-2 tissue inhibitor of metalloproteinase-2, IGFBP-7 insulin-like growth factor-binding protein 7, Ang-2 angiopoietin-2, OR odds ratio, *P < 0.05, **P < 0.01.

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